MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA type-c) is a 16-amino acid peptide encoded by a short open reading frame within the mitochondrial 12S rRNA gene. This discovery represented a paradigm shift in understanding mitochondrial biology, revealing that mitochondria actively produce signaling peptides that may influence cellular metabolism.
Research indicates that MOTS-c may influence AMPK activation, glucose metabolism, and cellular stress responses. Published studies have examined its effects on insulin sensitivity markers, exercise-related metabolic adaptations, and age-associated metabolic changes in various research models.
Research Applications
- Mitochondrial biology
- Metabolic research
- AMPK pathway studies
- Aging and longevity investigations
- Exercise physiology research
Strictly for laboratory research and scientific investigation.


